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Том 8 №4 2006 год - Нефрология и диализ

Опыт применения сертикана − нового ингибитора сигнала пролиферации при трансплантации органов (Обзор литературы)

Мойсюк Я.Г. Милосердов И.А.

Аннотация: В настоящее время трансплантация почки является наиболее эффективным методом заместительной почечной терапии, обеспечивая социальную реабилитацию и более высокое качество жизни пациентов по сравнению с диализной терапией [18, 34, 58]. Анализ результатов 11482 трансплантаций почки, выполненных в Канаде, показал, что 5-летняя выживаемость реципиентов выросла с 84 до 91% для операций, проведенных в 1981-1985, и 1995-1998 гг. соответственно [47]. При этом 5-летняя выживаемость трансплантатов за эти периоды также увеличилась с 63 до 80%. Вместе с тем, улучшение результатов трансплантации почки сопровождается экспоненциальным увеличением числа пациентов, находящихся в “листе ожидания”, что не может быть компенсировано количеством выполняемых операций. Так, на основании современных тенденций установлено, что к 2010 году только в США в “листе ожидания” на пересадку почки будет состоять 95550 ± 5478 пациентов, тогда как количество операций остается стабильным на протяжении последних лет и не превышает 12 000-14 000 в год [59].

Для цитирования: Мойсюк Я.Г., Милосердов И.А. Опыт применения сертикана − нового ингибитора сигнала пролиферации при трансплантации органов (Обзор литературы). Нефрология и диализ. 2006. 8(4):336-343. doi:

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Ключевые слова: иммуносупрессия, ингибиторы сигнала пролиферации, трансплантация органов

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