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Том 8 №2 2006 год - Нефрология и диализ

Подоцит: строение и роль в развитии нефротического синдрома (Обзор литературы)

Петросян Э.К.

Аннотация: Осмысление уникального молекулярного аппарата подоцита в последние годы позволило улучшить диагностику и создать классификацию болезней, которые назвали подоцитопатиями. Повреждение подоцитов часто ведет к реорганизации щелевой диафрагмы и структуры "ножек" подоцита. Результаты многочисленных исследований, приведенных в обзоре, позволили выделить четыре главные причины развития нефротического синдрома, обусловленные генетическими мутациями компонентов подоцита: а) изменение структуры щелевой диафрагмы; б) нарушение адгезивных способностей подоцита к базальной мембране; в) повреждение актинового цитоскелета подоцита и г) изменение в апикальной области мембраны подоцита.

Для цитирования: Петросян Э.К. Подоцит: строение и роль в развитии нефротического синдрома (Обзор литературы). Нефрология и диализ. 2006. 8(2):112-121. doi:

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Ключевые слова: нефротический синдром, подоцит, нефрин, подоцин, CD2AP, ZO-1, FAT, NPHS1, NPHS2

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