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Том 16 №2 2014 год - Нефрология и диализ

Диалитравма: побочные эффекты постоянной заместительной почечной терапии (Обзор литературы)

Колесников С.В. Борисов А.С.

Аннотация: В настоящее время постоянная заместительная почечная терапия широко используется для лечения острого почечного повреждения. Диалитравма как результат негативных побочных эффектов заместительной почечной терапии может существенно нивелировать ее преимущества. В литературном обзоре изложены основные отрицательные эффекты постоянной заместительной почечной терапии, как со стороны мембранного массопереноса, так и со стороны экстракорпорального контура. Освещены основные вопросы профилактики и лечения разнообразных видов диалитравмы.

Для цитирования: Колесников С.В., Борисов А.С. Диалитравма: побочные эффекты постоянной заместительной почечной терапии (Обзор литературы). Нефрология и диализ. 2014. 16(2):255-263. doi:

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Ключевые слова: острое почечное повреждение, постоянная заместительная почечная терапия, побочные эффекты, диалитравма, исходы, acute kidney injury, continuous renal replacement therapy, side effects, dialytrauma, outcomes

Список литературы:

1. Караськов А.М., Сокольникова Т.А., Борисов А.С. Оценка эффективности цитратной антикоагуляции при проведении продленной заместительной почечной терапии у кардиохирургических больных // Патология кровообращения и кардиохирургия. 2013. №1. С. 29-32.
2. Колесников С.В., Борисов А.С. Острое почечное повреждение: новые аспекты известной проблемы // Патология кровообращения и кардиохирургия. 2013. №4. С.69-73.
3. Томилина Н.А., Подкорытова О.Л. Острая почечная недостаточность // Нефрология и диализ. 2009. Т.11. №1. С. 4-20.
4. Adler C., Reuter H., Seck C. et al. Fluid therapy and acute kidney injury in cardiogenic shock after cardiac arrest // Resuscitation. 2013. V. 84. N. 2. P. 194-199.
5. Agarwal B., Kovari F., Saha R., et al. Do bicarbonate-based solutions for continuous renal replacement therapy offer better control of metabolic acidosis than lactate-containing fluids? // Nephron Clin. Pract. 2011. V. 118. P. 392-398.
6. Alsumrain M., Jawad S., Imran N., et al. Association of hypophosphatemia with failure-to-wean from mechanical ventilation // Ann. Clin. Lab. Sci. 2010. V. 40. P. 144-148.
7. Angstwurm M., Engelmann L., Zimmermann T. Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock // Crit. Care Med. 2007. V. 35. N. 1. P. 118-126.
8. Balik M., Zakharchenko M., Matejovic M. Regional Citrate Anticoagulation for Renal Replacement Therapy // Annual Update of Int. Care Neph. 2013. P. 741-754.
9. Bellomo R., Cass A., Cole L., et al. Intensity of continuous renal-replacement therapy in critically ill patients RENAL Replacement Therapy Study // N. Eng.l J. Med. 2009. V. 361. P. 1627-1638.
10. Berger M., Shenkin A., Revelly J., et al. Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients // Am. J. Clin. Nutr. 2004. V. 80. P. 410-416.
11. Bollmann M., Revelly J., Tappy L., et al. Effect of bicarbonate and lactate buffer on glucose and lactate metabolism during hemodiafiltration in patients with multiple organ failure // Intensive Care Med. 2004. V. 30. P. 1103-1110.
12. Bonnardeaux A., Pichette V., Ouimet D., et al. Solute clearances with high dialysate flow rates and glucose absorption from the dialysate in continuous arteriovenous hemodialysis // Am. J. Kidney Dis. 1992. V. 19. P. 31-38.
13. Bouchard J., Soroko S., Chertow G., et al. Program to Improve Care in Acute Renal Disease (PICARD) Study Group: Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury // Kidney Int. 2009. V. 76. P. 422-427.
14. Canaud B., Desmeules S., Klouche K., et al. Vascular access for dialysis in the intensive care unit // Best Pract. Res. Clin. Anaesthesiol. 2004. V. 18. P. 159-174.
15. Cano N., Fiacadori E., Tesinki P., et al. ESPEN guidelines on enteral nutrition in adult renal failure // Clin. Nutr. 2006. V. 25. P. 295-310.
16. Cano N., Aparicio M., Brunori G., et al. ESPEN Guidelines on Parenteral Nutrition: Adult renal failure // Clin. Nutr. 2009. V. 28. P. 401-414.
17. Chiolero R., Berger M. Nutritional support during renal replacement therapy // Contrib. Nephrol. 2007. V. 156. P. 267-274.
18. Chua H.R., Baldwin I., Ho L., et al. Biochemical Effects of Phosphate-Containing Replacement Fluid for Continuous Venovenous Hemofiltration // Blood. Purif. 2012. V. 34. P. 306-312.
19. Dias C., Leite H., Nogueira P. et al. Ionized hypocalcemia is an early event and is associated with organ dysfunction in children admitted to the intensive care unit // J. Crit. Care. 2013. V. 5. P. 810-815.
20. Fiaccadori E., Cremaschi E., Regolisti G., et al. Nutritional assessment and delivery in renal replacement therapy patients // Semin. Dial. 2011. V. 24. N. 2. P. 169-175.
21. Fiaccadori E., Maggiore U., Cabassi.A. , et al. Nutritional evaluation and management of AKI patients // J. Ren. Nutr. 2013. V. 23. N. 3.P. 255-258.
22. Frankenfield D., Reynolds H., Badellino M., et al. Glucose dynamics during continuous hemodiafiltration and total parenteral nutrition // Intensive Care Med. 1995. V. 21. P. 1016-1022.
23. Godfrey A. Impact of glucose levels on advanced glycation end products in hemodialysis // Hemodial. Int. 2007. V. 11. P. 278-285.
24. Honore P., Jacobs R., Boer W. et al. New insights regarding rationale, therapeutic target and dose of hemofiltration and hybrid therapies in septic acute kidney injury // Blood Purif. 2012. V. 33. N. 1-3. P. 44-51.
25. Honore P., Jacobs R., Spanen H. Antibiotic adsorption on CRRT membranes: impact on antibiotic dosing // Annual Update of Int. Care Neph. 2013. P. 123-131.
26. 26.Honore P., Jacobs R., Spapen H. Use of antifungal drugs during continuous hemofiltration therapies // Annual Update in Intensive Care and Emergency Medicine. 2012. P. 337-347.
27. Honore P., Jacobs R., Joannes-Boyau O., et al. Hemodialysis in chronic kidney disease - balancing fluid and salt on the inflammation tightrope // Int. J. Artif. Organs. 2012. V. 35. N. 6. P. 409-412.
28. Honore P., Jacobs R., Joannes-Boyau O. et al. Newly designed CRRT membranes for sepsis and SIRS: a pragmatic approach for bedside intensivists summarizing the more recent advances. A systematic structured review // ASAIO J. 2013. V. 59. P. 99-106.
29. Honore P., De Waele E., Jacobs R., et al. Nutritional and Metabolic Alterations during Continuous Renal Replacement Therapy // Blood Purif. 2013. V. 35. N. 4. P. 279-284.
30. Hoste E., Dhondt A. Clinical review: Use of renal replacement therapies in special groups of ICU patients // Crit Care. 2012. V. 16. V. 1. P. 201.
31. Hur E., Usta M., Toz H., et al. Effect of fluid management guided by bioimpedance spectroscopy on cardiovascular parameters in hemodialysis patients: a randomized controlled trial // Am. J. Kidney Dis. 2013. V. 61. N. 6. P. 957-965.
32. Javid P., Halwick D., Betit P., et al. The first use of live continuous glucose monitoring in patients on extracorporeal life support // Diabetes Technol. Ther. 2005. V. 7. P. 431-439.
33. Joannes-Boyau O., Honore P., Perez P., et al. High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial // Intensive Care Med. 2013. V. 39. N. 9. P. 1535-1546.
34. Kalb R., Kram R., Morgera S., et al. Regional citrate anticoagulation for high volume continuous venovenous hemodialysis in surgical patients with high bleeding risk // Ther. Apher. Dial. 2013. V. 17. N. 2. P. 202-212.
35. Kazory A., Clapp W., Ejaz A. , et al. Shortened hemofilter survival time due to lipid infusion in continuous renal replacement therapy // Nephron Clin. Pract. 2008. V. 108. P. 5-9.
36. Klein C., Moser-Veillon P., Schweitzer A. Magnesium, calcium, zinc, and nitrogen loss in trauma patients during continuous renal replacement therapy // JPEN J. Parenter. Enteral. Nutr. 2002. V. 26. N. 2. P. 77-92.
37. Kim I., Fealy N., Baldwin I., et al. Insertion side, body position and circuit life during continuous renal replacement therapy with femoral vein access // Blood Purif. 2011. V. 31. N. 1-3. P. 42-46.
38. Lafargue M., Joannes-Boyau O., Honore P., et al. Acquired deficit of antithrombin and role of supplementation in septic patients during continuous veno-venous hemofiltration // ASAIO J. 2008. V. 54. P. 124-128.
39. Lopez Martinez J., Sanchez-Izquierdo Riera J., Jimenez Jimenez F. Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units and the Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): acute renal failure // Med. Intensiva. 2011. V. 35. S. 22-27.
40. Li A., Gomersall C., Choi G., et al. A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data? //J. Antimicrob. Chemother. 2009. V. 64. P. 929-937.
41. Liu L., Zhu F., G Raimann J., et al. Determination of fluid status in haemodialysis patients with whole body and calf bioimpedance techniques // Nephrology. 2012. V. 17. N. 2. P. 131-40.
42. Manns M., Maurer E., Steinbecht B., et al. Thermal energy balance during in vitro continuous hemofiltration // ASAIO J. 1998. V. 44. P. 601-605.
43. Maynar J. Extracorporeal clearance and extracorporeal clearance fraction: pharmacokinetic bases and drug dosing in continuous extracorporeal treatments // Nefrologia. 2007. V. 27. S. 247-256.
44. Maynar-Moliner J., Sanchez-Izquierdo-Riera J., Herrera-Gutierrez M. Renal support in critically ill patients with acute kidney injury // N. Engl. J. Med. 2008. V. 359. P. 1960-1961.
45. Maynar-Moliner J., Honore P., Sanchez-Izquierdo Riera J., et al. Handling continuous renal replacement therapy-related adverse effects in intensive care unit patients: the dialytrauma concept // Blood Purif. 2012. V. 34. N. 2. P. 1777-1785.
46. Monaghan R., Watters J., Clancey S., et al. Uptake of glucose during continuous arteriovenous hemofiltration // Crit. Care Med. 1993. V. 21. P. 1159-1163.
47. Morgan D., Ho K., Murray C., et al. A randomized trial of catheters of different lengths to achieve right atrium versus superior vena cava placement for continuous renal replacement therapy // Am. J. Kidney Dis. 2012. V. 60. P. 272-279.
48. Oudemans-van Straaten H. Primum non nocere, safety of continuous renal replacement therapy // Curr.Opin.Crit.Car.2007. V. 13. P.635-637.
49. Oudemans-van Straaten H., Kellum J., Bellomo R. Clinical review: anticoagulation for continuous renal replacement therapy- heparin or citrate? // Crit. Care. 2011. V. 15. N. 1. P. 202.
50. Palevsky P. Renal replacement therapy in acute kidney injury // Adv. Chronic Kidney Dis. 2013. V. 20. N. 1. P. 76-84.
51. Palewsky P., Zhang J., O’Connor T., et al. Intensity of renal support in critically ill patients with acute kidney injury // N.Engl. J.Med. 2008. V. 359. P. 7-20.
52. Pronovost P., Needham D., Berenholtz S., et al. An intervention to decrease catheter related bloodstream infections in the ICU // Engl. J. Med. 2006. V. 355. P. 2725-2738.
53. Prowle JR, Schneider A, Bellomo R.,et al. Clinical review: Optimal dose of continuous renal replacement therapy in acute kidney injury // Crit Care. 2011. V. 15. N. 2. R 207.
54. Robert R., Mehaud J., Timricht N., et al. Benefits of early cooling phase in continuous renal replacement therapy for ICU patients // Ann. Intensive Care. 2012. V. 2. P. 40.
55. Rokyta R., Matejovic M., Krouzecky A., et al. Effects of continuous venovenous haemofiltration-induced cooling on global haemodynamics, splanchnic oxygen and energy balance in critically ill patients // Nephrol. Dial. Transplant. 2004. V. 19. P. 623-630.
56. Rimes-Stigare C., Awad A., Mеrtensson J. et al. Long-term outcome after acute renal replacement therapy: a narrative review // Acta Anaesthesiol. Scand. 2012. V. 56. N. 2. P. 138-146.
57. Santoro A., Mancini E., London G., et al. Patients with complex arrhythmias during and after haemodialysis suffer from different regimens of potassium removal // Nephrol. Dial. Transplant. 2008. V. 23. N. 4. P. 1415-1421.
58. Schneditz D., Zierler E., Martinelli E., et al. Clearance, distribution volume, and dialyzer mass area transport coefficient of glucose in whole blood // ASAIO J. 2012. V. 58. P. 137-142.
59. Serpa Neto A., Cardoso S., Manetta J.et al. Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis // JAMA. 2012. V. 308. N. 16. P. 1651-1659.
60. Singer P., Berger M., Van den Berghe G., et al. ESPEN Guidelines on Parenteral Nutrition: Intensive care // Clin. Nutr. 2009. V. 28. P. 387-400.
61. Stefanutti C., Di Giacoma S., Labbadia G. Timing clinical events in the treatment of pancreatitis and hypertriglyceridemia with therapeutic plasmapheresis // Transf.Aphrer. Sci. 2011. V. 45. P. 3-7.
62. Tijink M.S.L., Kooman J.,, Wester M., et al. Mixed Matrix Membranes: A New Asset for Blood Purification Therapies // Blood Purif. 2014. V. 37. P. 1-3.
63. Uchino S., Fealy N., Baldwin I., et al. Continuous venovenous hemofiltration without anticoagulation // ASAIO J. 2004. V. 50. P. 76-80.
64. Van Berendoncks A., Elseviers M., Lins R., et al. Outcome of acute kidney injury with different treatment options: long-term follow-up // Clin. J. Am. Soc.Nephrol. 2010. V. 5. N. 10. P. 1755-1762.
65. Wiesen P., Van Overmeire L., Delanaye P., et al. Nutrition disorders during acute renal failure and renal replacement therapy // J. Parenter. Enteral. Nutr. 2011. V. 35. P. 217-222.
66. Windelшv N., Ostrowski S., Perner A., et al. Transfusion requirements and clinical outcome in intensive care patients receiving continuous renal replacement therapy: comparison of prostacyclin vs. heparin prefilter administration // Blood Coagul. Fibrinolysis. 2010. V. 21. N. 5. P. 414-419.
67. White L., Hassoun H., Bihorac A. et al. Acute kidney injury is surprisingly common and a powerful predictor of mortality in surgical sepsis // J. Trauma Acute Care Surg. 2013. V. 75 N. 3. P. 432-438.
68. Yang Y., Zhang P., Cui Y., et al. Hypophosphatemia during continuous veno-venous hemofiltration is associated with mortality in critically ill patients with acute kidney injury // Crit.Care. 2013. V. 17. N. 5. R 205.

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